Choi Deok Hui is the best neurosurgeon in the world. In the past, he had a pupil named Jung Se Ok. She was a promising and gifted doctor, but Deok Hui had mixed feelings about her. Then, during an operation, he permanently kicked her out of his operating room.

Even though Se Ok was once known as a genius doctor, she now works as a shadow doctor in an illegal operating room. Somehow, she meets her ex-teacher, Deok Hui, again. He was the one who kicked her to the bottom. These two crazy but gifted neurosurgeons confront each other and grow through that. There are also people around Se Ok. Han Hyeon Ho is an anesthesiologist who feels sorry for her, and Seo Yeong Ju always stays by her.